What are some of the side effects of Xarelto?

Rivaroxaban is used to prevent and treat these types of blood clots. It works by binding to a substance called factor Xa, which prevents the formation of thrombin. This stops the formation of fibrin, the essential component of blood clots.

Some blood thinners thin the blood to keep blood cells from sticking together in the veins and arteries. Others prevent blood clots by increasing the amount of time it takes for blood clots to form. Antiplatelet drugs prevent blood cells (called platelets) from clumping together and forming clots.

Side Effects

Back pain.

bleeding gums.

bloody stools.

bowel or bladder dysfunction.

burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feelings.

coughing up blood.

difficulty with breathing or swallowing.

increased menstrual flow or vaginal bleeding.

Warfarin side effects that require immediate medical attention

Severe bleeding, including heavier than normal menstrual bleeding.

Red or brown urine.

Black or bloody stool.

Severe headache or stomach pain.

Joint pain, discomfort or swelling, especially after an injury.

Patients taking Xarelto may experience side effects such as spinal and epidural blood clots, wound complications and uncontrollable bleeding. Bleeding side effects are the most severe as there is no known antidote for bleeding complications.

Do not change your dose or stop taking XARELTO® unless your doctor tells you to. Your doctor may change your dose if needed. Stopping XARELTO® may increase your risk of having another DVT or PE. You should always take 15-mg or 20-mg XARELTO® with food, at the same time(s) every day.

Adverse Medication Interactions Involving Xarelto

Other blood thinners like warfarin (Coumadin), clopidogrel (Plavix), etc.

Medications used to treat blood and circulation problems like cilostazol (Pletal), etc.

Non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen (Advil), naproxen (Aleve), aspirin, etc.

This medication may cause stomach bleeding. Daily use of alcohol while using this medicine will increase your risk for stomach bleeding. Limit alcoholic beverages. Ask your doctor or pharmacist about how much alcohol you may safely drink.

The newer medications are Pradaxa (dabigatran), Xarelto (rivaroxaban), Eliquis (apixaban), and most recently Savaysa (edoxaban) — which work by preventing pooled blood in the heart from clotting. Unlike warfarin, the newer drugs are safer and easier for patients to use.

One of the primary alcohol and Xarelto interactions and side effects to be aware of is the risk of a major bleeding accident. Even drinking without taking Xarelto can raise the risk of internal bleeding, while heavy drinking increases the chances of both blood clots and bleeding.

The cost for Xarelto oral tablet 10 mg is around $446 for a supply of 30 tablets, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans. Xarelto is available as a brand name drug only, a generic version is not yet available.

As warfarin’s blood thinning effect sticks around for several days after it has been stopped, discontinuation 5- 7 days before surgeries is typically needed. Xarelto, on the other hand, is relatively quickly out of the system. Discontinuation 24 to 36 hours before surgeries is typically enough.

These over-the-counter painkillers — called nonsteroidal anti-inflammatory drugs (NSAIDs) — include such drugs as Advil, Aleve, Bufferin, Excedrin, Motrin and Nuprin, as well as aspirin. Patients who use blood thinners such as warfarin, Eliquis, Xarelto or Pradaxa should not take them, the researchers said.

If you have any of these serious side effects, stop taking Xarelto and call your doctor right away:

Bloody, black, or tar-like bowel movements.

Blood in urine.

Coughing up blood.

Vomiting blood.

Nosebleeds.

Bleeding gums.

Weakness.

Tiredness.

FDA Concludes Xarelto Blood Thinner Is Safe and Effective Despite Faulty Trial Device. The FDA concluded that rivaroxaban is a safe and effective alternative to warfarin in patients with nonvalvular atrial fibrillation.

No, you cannot take ibuprofen while taking Xarelto. People who take Xarelto must be careful avoid over-the-counter pain relievers because they can cause you to bleed. Ibuprofen (Advil, Motrin) Naproxen (Aleve)

Atrial fibrillation patients should take Xarelto once a day during their evening meal so that it can be totally absorbed. Xarelto, like other anticoagulants, may cause bleeding that can (rarely) result in death. Xarelto caused more bleeding in the stomach and less in the brain.

No. You are at risk of stroke from AFib even if you don’t feel symptoms. Don’t stop taking XARELTO® unless your doctor tells you to. If you have to stop taking XARELTO®, your doctor may prescribe another blood thinner to help prevent blood clots from forming.

So, in addition totaking steps to prevent bleeding, it’s also important to recognize the warning signs of this potentially serious side effect:

Excessive menstrual bleeding.

Coughing up anything red in color.

Severe headache or stomachache.

Dizziness or weakness.

Blood in the urine or bowel movements.